Roger Federer, Novak Djokovic, and Rafael Nadal have ruled tennis for two decades, accumulating a total of 66 Grand Slam titles between them.
The iconic trio, often referred to as the ‘big three’, consistently outshone their competitors on the ATP Tour, sharing the number one ranking (along with Andy Murray) for 18 years from 2004 to 2022.
Facing off against some of the greatest players in the sport’s history, their opponents frequently wondered what their careers might have looked like in a different era.
Players like Tomas Berdych, David Ferrer, Jo-Wilfried Tsonga, and Robin Soderling had opportunities to claim Grand Slam titles but ultimately fell short against the ‘big three’ in crucial final matches.
John Isner, who faced Djokovic, Federer, and Nadal numerous times, has now shared his perspective on which of the three was the hardest to compete against at their ‘absolute peak’.
John Isner Identifies Novak Djokovic as the Toughest Opponent at His Peak
In a recent appearance on the Tennis Channel, Isner was asked to identify the toughest player from the ‘big three’. He stated, “At their absolute peak, I would say Novak [Djokovic]. When he’s completely locked in, he’s the toughest for me.”
Isner acknowledged how formidable they all are but mentioned his challenges facing Nadal, saying, “I’ve played Rafa [Nadal] numerous times on clay, which is difficult.”
He reminisced about a match at the China Open, where he felt he had no chance against Djokovic, noting Djokovic’s impressive 25-0 record at that tournament.
In that quarterfinal match, Isner remarked, “I got completely outplayed, losing two sets to love. Djokovic was fully locked in, and it showcased the best level of tennis I’d ever faced.”
Has John Isner Ever Defeated Novak Djokovic on the ATP Tour?
Initially, Isner lost his first two encounters with Djokovic in 2010, but managed to turn the tide during their third meeting at the 2012 Indian Wells final, winning in three sets.
He continued his success against Djokovic in 2013 at the Cincinnati Open, securing a second victory. However, Djokovic quickly regained control, winning their subsequent seven matches to improve his head-to-head record against Isner to 10-2.
With ten career losses against Djokovic, it’s no surprise Isner considers him to be his most challenging opponent.
